Peer-Reviewed Publications

“Rhabdomyolysis: Clinical Update, Pathogenesis, Treatment and Anesthesia Considerations,” Torres P, Helmstetter J, Kaye AM, Kaye AD, Ochsner Journal, 2015:15(1), 58–69

“Case Report: Transient glaucoma after an Epidural Steroid Injection,” Manjiani D, Kaye AD, Ocshner Journal, 2015:15(1),79-82

“Novel Improvements in Perioperative Sterility,” Prabhakar A, Wyche MQ, Ehrhardt KP, Ma JG, ElHassan, AO, Urman R, Kaye AD, Journal Medical Practice Management, 2015:suppl, 48-50

“Complications of Non-Operating Room Procedures: Outcomes from the National Anesthesia Outcomes Registry,” Chang B, Dutton R, Diaz J, Kaye AD, Urman RD, Journal of Patient Safety, 2015:suppl, 1-8

“Improving Operating Room Efficiency and Utilization in a Level One Academic Medical Center: System Review and Effective Strategies,” Kaye AD, McDowell JL, Diaz JH, Buras JA, Young AE, Urman RD, Journal of Patient Safety, 2015,s uppl:24-29

“Intrapelvic Obturator Internus Muscle Injections: A Novel Fluoroscopic Technique,” Valovska A, Zaccagnino MP, Weaver MJ, Valovski I, Kaye AD, Urman RD, Pain Physician, 2015:Mar-Apr;18(2):E237-243

“Perceiving Operating Room Communication: A Survey,” Wyche MQ, Lemay A, Tiemann DD, Billeaud CB, Ma JG, ElHassan AO, Fox ME, Diaz JH, Bell L, Urman RD, Kaye AD, Journal Medical Practice Management, 2015: suppl:36-40

“Comparison of the Efficacy of Saline, Local Anesthetics, and Steroids in Epidural and Facet Joint Injections for the Management of Spinal Pain: A Systematic Review of Randomized Controlled Trials,” Manchikanti L, Nampiaparampil DE, Manchikanti KN, Falco FE, Singh V, Benyamin RM, Kaye AD, Sehgal N, Soin A, Simopoulos TT, Bakshi S, Gharibo CG, Gilligan CJ, Hirsch JA, Surgical Neurology International, suppl 4, vol 6, 2015, 194-235

“A Five-star Doctor? - Online Rating of Physicians by Patients in an Internet Driven World," Ma JG, Kaye AD, Bean M, Ruan X., Pain Physician, 2015; 18:E15-E17 | ISSN 2150-1149

“Minimally Invasive or Non-Invasive Cardiac Output Measurement: An Update," Sangkum L, Liu GL, Yu L, Chen M, Kaye AD, Liu H., Anesthesia & Analgesia, 2015

“A Comparison between Office and Ambulatory Practices: Analysis from the National Anesthesia Clinical Outcomes Registry,” Jani SR, Shapiro F, Kordylewski H, Diaz JH, Kaye AD, Dutton RP, Urman RD. Journal of Ambulatory Care Management, 2015

“A Systematic Guide for Peer Reviewers for a Medical Journal,” Garfield J, Kaye AD, Dutton RP, Kolinsky D, Urman RD. Journal Medical Practice Management, 2015, suppl, 13-17

“Perioperative Medicine Challenges, an Update,” Kaye AD, Urman RD, Journal Medical Practice Management, 2015: suppl, 1

“The Use of Emergency Manuals in Perioperative Crisis Management: A Cautious Approach,” Szabo A, August DA, Klainer S, Miller AD, Kaye AD, Raemer DB, Urman RD, Journal Medical Practice Management, 2015: suppl, 8-12

“Concepts in Creating an Evidence-based Anesthetic Protocol for Robot-Assisted Laparoscopic Pelvic Surgery,” Prabhakar A, Donnenfeld BL, Kaye AD, Feltmate CM, Urman RD. Journal Medical Practice Management, 2015: suppl, 18-23

“Medication Errors in Anesthesia,” Prabhakar A, Kaye AD, ElHassan AO, Malapero RJ, Urman RD, Journal Medical Practice Management, 2015: suppl, 41-43

“Peer Review Process and Publications in Medical Journals: Facts, Fiction, and Bias,” Manchikanti L, Kaye AD, Boswell M, Hirsch J. Pain Physician, 2015; 18:E1-E14 | ISSN 2150-1149

“Different analgesic effect of intrathecal endomorphin 2 on thermal hyperalgesia and evoked inflammatory pain in ovariectomized rats,” Zhao XH, Zhao YQ, Zhu C, Chen L, Hu W, Zhang T, Dong YL, Wu SX, Kaye AD, Li YQ, Wang W, Pain Physician, 2015; 18: 1533-3159

“Effects of Systemic Magnesium on Postoperative Analgesia: Is current evidence strong enough?” Guo BL, Lin Y, Hu W, Wang YY, Zheng CX, Cheng ZB, Wu HH, Dong YL, Bai L, Kaye AD, Wu SX, Wang W, Duan JH, Qu Y, Pain Physician, 2015;18;405-417

“Primer for Billing in Pain Management,” Yong RJ, Nelson E, Kaye AD, Journal Patient Safety, 2015:suppl, 51-54

“Drug-Induced Acute Pancreatitis: A Review,” Jones MR, Hall OM, Kaye AM, Kaye AD, Ochsner Journal, 2015; 15:45–51

“The Prognostic Value of C-X-C Chemokine Receptor 4 in Primary Lung Cancer: A Systematic Review and Meta-Analysis,” Bai L, Guo CH, Wu HH, Chen-Wang J, Kaye AD, Wang JS, Duan XY, Guo YM, BMC Cancer, 2015

“Challenges in Patient-Centered Opioid Therapy for Chronic Pain,” Ruan X, Li G, Kaye AD, Pain Practice, 2015

"Hydrocodone bitartrate for chronic pain,” Manchikanti L, Atluri S, Kaye AM, Kaye AD, Drugs of Today -- Prous Thomson Reuters – Monograth, 2015;51(7): 415

“Tanshinone IIA attenuates chronic pancreatitis-induced pain in rats via downregulation of HMGB1 and TRL4 expression in the spinal cord.” Wang YS, Wang LH, Li YY, Kang Y, Zhang J, Liu ZQ, Wang K, Kaye AD, Chen L, Pain Physician; 18:E615-E628 | ISSN 2150-1149

“Clinical Application of Intravenous Lipid Emulsion Therapy,” Muller SH, Diaz JH, Kaye AD, Journal of Anesthesia, December 2015, Volume 29, Issue 6, pp 920-926

“Effects of Anesthetic Management on Early Postoperative Recovery, Hemodynamics, and Pain after Supratentorial Craniotomy,” Ayrian E, Kaye AD, Varner CL, Guerra C, Vadivelu N, Urman RD, Zelman V, Lumb PD, Rosa G, Biotta F. Journal Clinical Medicine Research, 2015 Oct; 7(10):731-41. doi: 10.14740/jocmr2256w.

“Do epidural injections provide short and long-term relief for lumbar disc herniation? A systemic review,” Manchikanti L, Benyamin RM, Falco FE, Kaye AD, Clinical Orthopaedics and Related Research, June 2015, 473, issue 6, 1940-56

“Pros and Cons of Opioids and Prediction of Sustained Use Provides Long-Awaited Answers with Clarity,” Manchikanti L, Atluri S, Grider JS, Kaye AD, Clinical Journal on Pain, 2015 Jul;31(7):672

“The Land of the Free (letter to the editor),” Ruan X, Luo JJ, Kaye AD, Lancet Psychiatry, 2015 Jul;2(7):588-9

“Does Tea Extract Supplementation Benefit Metabolic Syndrome and Obesity? A Systematic Review and Meta-Analysis,” Li XM, Wu HH, Wu YJ, Quian XH, Shi ZL, Wang XM, Kaye AD, Wang W, 2016

“Validity of Enriched Enrollment, Randomized Withdrawal Trials,” (letter to the editor), Ruan X, Kaye AD, Pain Journal,2016 Jan;157(1):280. doi: 10.1097/ j.pain.0000000000000347.

“Analgesic Effects of Danggui-Shaoyao-San on Various ‘Phenotypes’ of Nociception and Inflammation in a Formalin Model,” Yin JB, Zhou KC, Wu HH, Hu W, Ding T, Zhang T, Wang LY, Kou JP, Kaye AD, Wang W, Molecular Neurobiology, 2016, DOI 10.1007/s12035-015-9606-3

“A Case of Tracheobronchial Obstruction Originating from a Posterior Pharyngeal Thrombus Related to a Mandibular Ameloblastoma Resection,” Prabhakar A, Woodall AK, Kaye AD, Anesthesia & Analgesia Case Reports, 2016

“A Best-Evidence Systematic Appraisal of the Diagnostic Accuracy and Utility of Facet (Zygapophysial) Joint Injections in Chronic Spinal Pain,” Boswell MV, Manchikanti L, Falco FJE, Sehgal N, Kaye AD, Atluri S, Bakshi S, Bryce D, Buenaventura R, Diwan S, Gharibo CG, Gupta S, Jha S, Manchikanti KN, Nampiaparampil DE, Robinson M, Simopoulos TT, Soin A, Vallejo R, Hirsch JA, Pain Physician, 2015; 18:E497-E533 | ISSN 2150-1149

"Cervical Zygapophysial (Facet) Joint Pain: Effectiveness of Interventional Management Strategies,” Manchikanti L, Hirsch JA, Kaye AD, Boswell MV, Postgrad Medical Journal, 2015 Dec 10:1-15

“A Systematic Appraisal Review of Efficacy and Best Evidence Synthesis of Therapeutic Facet Join Interventions in Managing Chronic Spinal Pain,” Manchikanti L, Falco FJE, Kaye AD, Boswell MV, Atluir S, Bakshi S, Boutwell KM, Gharibo CG, Grami V, Gider JS, Gupta S, Hansen H, Helm S, Jha SS, Manchikanti KN, Mann DP, Nampiaparampil DE, Sharma ML, Shroyer LN, Simopoulos TT, Singh V, Soin A, Vallejo R, Wargo BW, Hirsch JA, Pain Physician, 2015; 18: | ISSN 1533-3159

"Tramadol, Pharmacology, Side Effects and Serotonin Syndrome, a Review,” Beakley BD, Kaye AM, Kaye AD, Pain Physician, 2015; 18: ISSN 1533-3159

“Practice Variations in Anesthetic Care and its Effect on Clinical Outcomes for Primary Total Hip Replacements,” Gabriel RA, Kaye AD, Jones MR, Dutton RP, Journal of Arthroplasty, 2015 Aug 29. pii: S0883-5403(15)00785-8. doi: 10.1016/j.arth.2015.08.031

“Emergency department utilization and subsequent prescription drug overdose death (letter to the editor),” Ruan X, Kaye AD. Annals of Epidemiology, 2015 Aug 20 pii: S1047-2797(15)00346-4. doi: 10.1016/j.annepidem.2015.07.013

“Efficacy of Cervical Interlaminar Epidural Steroid Injections (letter to the editor),” Manchitanti L, Atluri S, Kaye AD, Hirsch J, Korean Journal of Radiology, 2015 Sep-Oct;16(5):1171-2. doi: 10.3348/kjr.2015.16.5.1171

“Neuroprotective Effects of Ginsenoside Rd on Infrasound Induced Central Nervous System Impairment: In Vitro and In Vivo Evidence,” Ma L, Cheng HR, Hu W, He H, Shi M, Gong XP, Zhang GY, Liu XD, Kaye AD, Zhao G, Shen XF, Scientifc Reports, 2015

“Alendronate for Treatment of Glucocorticoid-Induced Osteoporosis: a Systematic Review and Meta-Analysis,” Zhu C, Wang YK, Ding T, Yang L, Liang W, Hu XY, Mo Li, Kaye AD, Ye ZX, Wang Z, Luo ZJ, Plos One, 2015

“Tragedy of Implementation of ICD-10-CM as ICD-10: Is the Cart Before the Horse or Tragic Paradox of Misinformation and Ignorance?” Manchikanti L, Kaye AD, Singh V, Boswell MV. Pain Physician, 2015; 18:E485-E495 ISSN 2150-1149

“Abuse-Deterrent Formulations of Prescription Opioids (letter to the editor)," Ruan X, Chiravuri S, Kaye AD. JAMA Psychiatry,2015 Jul 8

“A Systemic Review of Efficacy and Best Evidence Synthesis of Therapeutic Facet Joint Interventions in Managing Chronic Spinal Pain,” Manchikanti L, Kaye AD, Boswell MV, Bakshi S, Gharibo CG, Grami V, Grider JS, Gupta S, Jha S, Mann DP,Nampiaparampil DE, Sharma ML, Shroyer LN, Singh V, Soin A, Vallejo R, Wargo BW, Hirsch JA, Pain Physician, 2015; 18:E535-E582 • ISSN 2150-1149

“Value of Examination under Fluoroscopy for the Assessment of Sacroiliac Joint Dysfunction,” Eskander JP, Ripoll JG, Calixto F, Beakley BD, Baker JT, Healy PJ, Gunduz OH, Shi L, Clodfelter JA, Liu J, Kaye AD, Sharma S. Pain Physician, 2015;18;E781-E786

“Cervical Transforaminal with Low-Dose Local Anesthetic is not a Safeguard for Neurological Complications (letter to the editor)," Manchikanti L, Kaye AD, Boswell M, Hirsch J, Pain Medicine,2015 Sep 26. doi: 10.1111/pme.12922

“Efficacy of Epidural Injections in Managing Chronic Spinal Pain: A Best Evidence Synthesis.” Kaye AD, Manchikanti L, Abdi S, Atluri S, Bakshi S, Baenyamin R, Boswell MV, Buenaventura R, Candido KD, Cordner HJ, Datta S, Doulatram G, Gharibo CG, Grami V, Gupta S, Jha S, Kaplan ED, Malla Y, Manchikanti KN, Mann DP, Nampiaparampil DE, Racz G, Raj P, Rana MV, Sharma ML, Singh V, Soin A, Staats PS, Vallegjo R, Wargo B, Hirsch JA. Pain Physician 2015; 18: ISSN 1533-3159

“Comparative Study of Three Different Supraglottic Airway Devices in Simulated Difficult Airway Situations,” Thierbach AO, Piepho T, Göbler S, Rützler K, Frass M, Kaye AD, Robak O, Minerva Anestesiologica Journal, 2015 December;81(12):1311-131

“Prescription Opioid Duration of Action and the Risk of Unintentional Overdose (letter to editor)," Ruan X, Wu J, Kaye AD, JAMA Internal Medicine 2015 Sep 1;175(9):1582-1583. doi: 10.1001/jamainternmed.2015.3256

“The Role of Participation Sampling and Statistical Analysis in Medical Research (letter to the editor)," Vo N, Ruan X, Kaye AD, European Journal of Applied Physiology, February 2016, Volume 116, Issue 2, 439-440

“Survival Strategies for Tsunami of ICD-10-CM for Interventionalists: Pursue or Perish!” Manchikanti L, Hammer MJ, Boswell MV, Kaye AD, Hisrch JA. Pain Physician, 2015;18;E685-E712

“Description of Optimal Angle of Needle Insertion for L5 Transforaminal Epidural Injection Leads to Complications,” Manchikanti, L, Atluri S, Benyamin RM, Kaye AD, Pain Physician, 2015;18;E937-E938

“Ketamine in the Perioperative Setting,” Vadivelu N, Schermer E, Maria M, Kodumudi V, Du G, Thomas D, Urman R, Kaye AD, Journal of Anaesthesiology Clinical Pharmacology, October-December 2015 | Vol 31 | Issue 4; 1-9

“Epidemiology, Pathogenesis, Diagnosis, and Perioperative Management of Dextrocardia: A Comprehensive Review,” Rappaport Y, Fox CJ, Kaye AD, Journal of Anesthesia, Volume 29, Issue 5 (2015), Page 769-785

“Is it Platelet-rich Plasma a Future Therapy in Pain Management?” Knezevic NN, Candido K, Desai R, Kaye AD. Medical Clinics of North America, 100 (2016) 199–217.

“Abuse-Deterrent Formulations: Transitioning the Pharmaceutical Market to Improve Public Health and Safety,” Ruan X, Kaye AD, Theraputic Advances in Drug Safety, 2015 Oct;6(5):196-197

“Description of Optimal Angle of Needle Insertion for L5Transforaminal Epidural Injection Leads to Complications,” Manchikanti L, Atluri S, Benyamin RM, Kaye AD. Pain Physician, 2015 Sep-Oct;18(5):E937-938

“Comment on the Evaluation of the Effectiveness of Hyaluronidase in the Selective Nerve Root Block of Radiculopathy," Manchikanti L, Kaye AD. Asian Spine Journal, 2015 Dec;9(6):995-6. doi: 10.4184/asj.2015.9.6.995

“Letter to the Editor: A report of Spinal Subdural Abscess Provides Incomplete and Inaccurate Information,” Manchikanti L, Atluri S, Kaye AD, Hirsch JA. Journal Neurosurgical Spine. 2016 Jan 1:1-2

“Efficacy of an Acute Pain Titration Protocol Driven by Patient Response to a Simple Query: Do You Want More Pain Medication? (letter to editor)," Ruan X, Kaye AD. Annals of Emergency Medicine, 2015 Dec;66(6):687-8. doi: 10.1016/j.annemergmed.2015.07.523

“Epidural Injections for Lumbar Radiculopathy and Spinal Stenosis: A Comparative Systemic Review and Meta-Analysis,” Manchikanti L, Knezevic N, Boswell MV, Kaye AD, Hirsch JA. Annals of Internal Medicine, 2015

"Measuring the Quality of Care for Patients with Traumatic Brain Injury (letter to editor)," Ruan X, Kaye AD. JAMA Surgery,2015 Nov 18:1. doi: 10.1001/ jamasurg.2015. 4224

“Botulinum Toxin: Pharmacology and Therapeutic Roles in Pain States,” Patil S, Banalore S, Willett O, Thompkins T, Hermann R, Ramanthan S, Cornett E. Fox C, Kaye AD. Current Pain Headache Reports, 2016 Mar;20(3):15. doi: 10.1007/s11916-016-0545-0

“The Role of Acupuncture in Pain Management,” Patil S, Bangalore S, Sen S, Bral M, Reddy S, Bradley K, Cornett E, Fox C, Kaye AD. Current Pain Headache Reports, 2016 Mar;20(4):22

“New Labor Pain Treatment Options,” Koyyalamudi V, Sidhu G, Cornett E, Nguyen V, Labrie-Brown C, Fox CJ, Kaye AD. Current Pain Headache Reports, 2016 Jan;20(2):11. doi: 10.1007/s11916-016-0543-2

“Transition from Injectable to Percutaneous Local Anesthetic Therapy in a Patient with Post-Herpetic Neuralgia,” Riopelle J, Kaye AD. Pain Physician. 2016 Feb;19(2):E359-60

“Emerging Advances in Neurostimulation for the Treatment of Facial Pain,” Maniam R, Kaye AD, Vadivelu N, Urman RD. Current Pain Headache Reports, 2016 Mar; 20(4):24

“New Pain Management Options for the Surgical Patient on Methadone and Buprenorphine,” Sen S, Arulkumar S, Cornett EM, Gayle JA, Flower RR, Fox CJ, Kaye AD. Current Pain Headache Reports,2016 Mar;20(3):16. doi: 10.1007/s11916-016-0549-9

“Pain in the Elderly,” Jones MR, Ehrhardt KP, Ripoll JG, Sharma B, Padnos IW, Kaye RJ, Kaye AD. Current Pain Headache Reports, 2016 Mar;20(4):23

“Post Herpetic Neuralgia, A Review,” Hadley GR, Gayle JA, Ripoll J, Jones MR, Argoff CE, Kaye AD. Current Pain Headache Reports, 2016 Mar;20(3):17. doi: 10.1007/s11916-016-0548-x

“National Perioperative Outcomes for Intrathecal Pump, Spinal Cord Stimulator, and Peripheral Nerve Stimulator Procedures,” Abrecht CR, Gabriel RA, Dutton RP, Kaye AD, Michna E, Urman RD. PainPhysician, 2015 Nov;18(6):547-54. ISSN 1533-3159

“Comment: Adverse Drug Reactions in Pediatric Emergency Medicine,” Ruan X, Rubin RE, Kaye AD. Annals of Pharmacotherapy, 2016 Jan 29. pii: 1060028015627311

“Child Mental Health Services in the Emergency Department-Disparities in Access,” Ruan X, Kaye AD. Pediatric Emergency Care, 2016 Feb;32(2):e2

“A Seamless Navigation of ICD-10-CM for Interventional Pain Physicians: Is a Rude Awakening Avoidable?” Manchikanti L, Hammer MJ, Boswell MV, Kaye AD, Hirsch JA. Pain Physician, 2016 Jan;19(1):E1-E14

“TO THE EDITOR: Re: Suri, P. et al. Short-term Improvements in Disability Mediate Patient Satisfaction After Epidural Corticosteroid Injections for Symptomatic Lumbar Spinal Stenosis,” Manchikanti L, Kaye AD, Hirsch JA. Spine, 2016 Feb;41(3):E183. doi: 10.1097/BRS.0000000000001357

“Acetaminophen, a Reasonable Option, but not a Panacea (letter to the editor)," Ruan X, Narahari P, Kaye AD. Journal Opioid Management, 2016 Jan-Feb;12(1):16-17. doi: 10.5055/jom.2016.0317

“Simple Solution for a Complex Problem: Rewriting the Script (letter to the editor)," Ruan X, Chiravuri S, Kaye AD. Journal Opioid Management, 2016 Jan-Feb;12(1):14-15. doi: 10.5055/jom.2016.0316

“Multimodal nociceptive mechanisms underlying chronic pelvic pain (letter to the editor)," Ruan X, Clarke RC, Kaye AD. American Journal of Obstetrics Gynecology. 2016 Mar 2. pii: S0002-9378(16)00392-6. doi: 10.1016/j.ajog.2016.02.050

“Efficacy of Epidural Injections in Managing Chronic Spinal Pain: A Best Evidence Synthesis,” Kaye AD, Manchikanti L, Abdi S, Atluri S, Bakshi S, Benyamin R, Boswell MV, Buenaventura R, Candido K, Cordner HJ, Datta S, Goulatram G, Gharibo CG, Grami V, Gupta S, Kaplan ED, Malla Y, Mann DP, Nampiaparampil D, Racz G, Raj P, Rana MV, Sharma ML, Singh V, Soin A, STaats PS, Vallejo R, Wargo BW, Hirsch JA. Pain Physician ,2015; 18:E939-E1004 | ISSN 2150-1149

“Analyzing the Relationship between Nonmedical Prescription-Opioid use and Heroin Use (letter to the editor)," Ruan X, Wyche MQ 3rd, Kaye AD. Journal Opioid Management, 2016 Jan-Feb;12(1):11-14. doi: 10.5055/jom.2016.0315.s

“Chronic Opioid Therapy after Lumbar Fusion Surgery for Degenerative Disk Disease in Workers' Compensation Patients (letter to editor)," Ruan X, Kaye AD, Clinical Journal of Pain. 2016, Feb;32(2):186. doi: 10.1097/AJP.0000000000000326

“Online Reviews of Physicians,” Ruan X, Bordelon GJ, Kaye AD. JAMA Dermatology, 2016 Mar 1;152(3):350. doi: 10.1001/jamadermatol.2015.6164

"Minimally invasive or noninvasive cardiac output measurement: an update," Sangkum L, Liu GL, Yu L, Yan H, Kaye AD, Liu H. Journal of Anesthesiology, 2016 Mar 9, pp. 1-20

"Utilization of Femoral Nerve Blocks for Total Knee Arthroplasty: a National Registry Analysis," Gabriel RA, Kaye AD, Nagrebetsky A, Jones MR, Dutton RP, Urman RD, Journal of Arthroplasty, 2016 Feb 9. pii: S0883-5403(16)00120-0. doi: 10.1016/j.arth.2016.02.002

“Different Influences of Lipofection and Electrotransfection on In Vitro Gene Delivery to Primary Cultured Cortex Neurons,” Zhang XS, Huang J, Zhan CQ, Chen J, Li T, Kaye AD, Wu SX, Xiao L, Pain Physician, 2016; 19: ISSN 1533-3159

“Intrathecal baclofen trials: complications and positive yield in a pediatric cohort (letter to the editor)," Ruan X, Kaye AD. Journal of Neurosurgery Pediatrics, 2016 Mar 18:1

“Feasibility and Utility of the Individualized Hydrocodone Therapy Based on Phenotype, Pharmacogenetics, and Pharmacokinetic Dosing,” Ruan X, Bumgarner GW, Labrie-Brown C, Kaye AD. Clinical Journal of Pain. 2016 Feb 17

“Multimodal Anesthesia with the Addition of Methadone is Superior to Epidural Analgesia: A Retrospective Comparison of Intraoperative Anesthetic Techniques and Pain Management for 124 pediatric patients Undergoing the Nuss procedure (letter to the editor)," Ruan X, Gayle J, Kaye AD, Journal of Pediatric Surgery, 2016 Mar 2. pii: S0022-3468(16)00131-7. doi: 10.1016/j.jpedsurg.2016.01.022

“Epidural Injections for Lumbar Radiculopathy and Spinal Stenosis: A Comparative Systemic Review and Meta-Analysis,” Manchikanti L, Knezevic N, Boswell MV, Kaye AD, Hirsch JA. Pain Physician, 2016 Mar;19(3):E365-E410

“Defining Chronic Pain,” Ruan X, Kaye AD. Journal of Rheumatology, 2016 Apr;43(4):826-7. doi: 10.3899/jrheum.150807

“Opportunities for Exploring and Reducing Prescription Drug Abuse through Social Media,” Ruan X, Kaye AD. Journal of Addictive Disorders, 2016 Apr 6:0

“Dexmedetomidine Premedication Dose-Dependently Attenuates Seizures and Negative Behavioral Emotions Via Inhibition of p-ERK Over-Expression in the Amygdala in a Ropivacaine-Induced Seizure Model in Mice,” Zhai MZ, Wu HH, Yin JB, Hu W, Cui YY,, Mei XP, Zhang H, Shen XF, Kaye AD, Chen GZ, Molecular Neurobiology, 2016 May;53(4):2636-46. doi: 10.1007/s12035-015-9276-1

“Relationship of Industry Sponsorship to Results of Cost-effectiveness Analyses of Drugs Used in Breast Cancer Treatment,” Ruan X, Bumgarner GW, Kaye AD. JAMA Oncology, 2016 Apr 1;2(4):548-549. doi: 10.1001/jamaoncol.2016.0139

“Pain Control in the Presence of Drug Addiction,” Vadivelu N, Lumermann L, Zhu R, Kodumudi G, Elhassan AO, Kaye AD. Current Pain Headache Report, 2016 May;20(5):35. doi: 10.1007/s11916-016-0561-0. Review

“Analysis of Prescription Patterns in Opioid Deaths Shows Startling Findings: Who is prescribing controlled medications to patients who die of prescription drug abuse?" Manchikanti L, Kaye AD. American Journal of Emergency Medicine. 2016 Jan.;34(1):30-5. Am J Emerg Med. 2016 Feb 2. pii: S0735-6757(16)00045-0. doi: 10.1016/j.ajem.2016.01.035

“Validity of enriched enrollment, randomized withdrawal trials,” Ruan X, Kaye AD. Pain, 2016 Jan;157(1):280. doi: 10.1097/j.pain.0000000000000347

“Current State of Opioid Therapy and Abuse,” Manchikanti L, Kaye AM, Kaye AD. Current Pain Headache Report, 2016 May;20(5):34. doi: 10.1007/s11916-016-0564-x

“Preventing chronic postoperative pain: Still a long way to go… (letter to editor)," Ruan X, Mancuso K, Kaye AD, Anesthesia, 2016, Vol 70 (S1), 2060

“Drug Formulation Advances in Extended Release Medications for Pain Control,” Jones MR, Carney MJ, Kaye RJ, Prabhakar A, Kaye AD. Current Pain Headache Report, 2016 May;20(6):36. doi: 10.1007/s11916-016-0565-9

"Analysis of Defibrotide Responses in the Feline Pulmonary Vascular Bed," Kaye AD, Skonieczny BD, Kaye AJ, Harris ZI, Luk EJ, American Journal of Therapeutics, 2016 May-Jun;23(3):e757-65. doi: 10.1097/MJT.0000000000000010

“Nocebo Effect of Informed Consent in Interventional Procedures (letter to editor)," Ruan X, Kaye AD. Clinical Journal of Pain, 2016 May;32(5):460-2. doi: 10.1097/AJP.0000000000000332

“Species Variation in Effects of Intrathecal κ-Opioid Receptor Agonist on Morphine-Induced Itch and Antinociception,” Ruan X, Bumgarner GW, Kaye AD. Regional Anesthesia and Pain Medicine, 2016 May-Jun;41(3):414

“Epidural Corticosteroid Injections for Radiculopathy and Spinal Stenosis,” Manchikanti L, Kaye AD, Hirsch JA. Annals of Internal Medicine, 2016 May 3;164(9):633. doi: 10.7326/L15-0566

“Are transdermal opioids contraindicated in patients at risk of suicide?” Ruan X, Labrie-Brown C, Kaye AD. European Journal of Anesthesiology, 2016 May 9

“Peritonsillar morphine infiltration to prevent early postoperative pain after tonsillectomy,” Ruan X, Salinas OJ, Kaye AD. European Journal of Anesthesiology, 2016 May 17

“Kappa Opioid Agonists, Emerging Therapeutic Roles,” Jones MR, Kaye AD, Kaye AJ, Urman R, Journal of Opioid Management, 2016 Mar-Apr;12(2):101-107. doi: 10.5055/jom.2016.0321

“Identifying cases of heroin toxicity where 6-acetylmorphine (6-AM) is not detected by toxicological analyses,” Ruan X, Chiravuri S, Kaye AD. Forensic Science, Medicine, Pathology, 2016 May 26, 1-2, DOI 10.1007/s12024-016-9783-z

“Response to Linares et al. on Personalized Oxycodone Dosing,” Ruan X, Bumgarner GW, Kaye AD. Pain Medicine, 2016 Jun 10. pii: pnw112

“Development of Effective Prophylaxis Against Intraoperative Carcinoid Crisis,” Woltering EA, Wright AE, Stevens MA, Wang YZ, Boudreaux JP, Mamikunian G, Riopelle JM, Kaye AD, Journal of Clinical Anesthesia, 2016 Aug;32:189-93. doi: 10.1016/j.jclinane.2016.03.008

“Patient Satisfaction in the Chronic Pain Clinic,” Ruan X, Chiravuri S, Kaye AD. Regional Anesthesia Pain Medicine, 2016 Jul-Aug;41(4):550-1

“Abuse-Deterrent Formulations and the Prescription Opioid Abuse Epidemic in the United States Lessons Learned From OxyContin (letter to the editor),” Ruan X, Chiravuri S, Kaye AD, JAMA Psychiatry,2 015 May;72(5):424-30. doi: 10.1001/jamapsychiatry.2014.3043

“Patient-Reported Reasons for Emergency Department Visits in the Urban Medicaid Population (letter to the editor),” Ruan X, Hu N, Kaye AD, American Journal of Medical Quality, 2015 Sep-Oct;30(5):496. doi: 10.1177/1062860615589594

“Using postmortem blood and urine norfentanyl/fentanyl ratios in the investigation of fentanyl-related deaths,” Ruan X, Chiravuri S, Kaye AD. Clinical Toxicology (Phila). 2016 Jun 17:1

“From Death to Death Certificate: a Call for Preventing Autopsy from Dying,” Ruan X, Chiravuri S, Kaye AD, Journal of Medical Toxicology, 2016 Jun 21

“Association of body mass index and choice of suicide methods,” Ruan X, Nguyen V, Kaye AD, Journal of Forensic and Legal Medicine, 2016 Jun 18;42:106-107. doi: 10.1016/j.jflm.2016.06.003

"Meloxicam prevents COX-2-mediated post-surgical inflammation but not pain following laparotomy in mice," Ruan X, Kaye RJ, Kaye AD.European Journal of Pain, 2016 Aug;20(7):1194-5. doi: 10.1002/ejp.871

”Consumption of and Satisfaction with Health Care Among Opioid Users with Chronic Non-Malignant Pain (letter to the editor)," Ruan X, Kaye AD, Acta Anesthesiological Scandinavica, 2016 Feb;60(2):274-5. doi: 10.1111/aas.12600

“Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice,” Muller SH, Diaz JH, Kaye AD, Journal of Louisiana State Medicial Society, 2016 May-Jun;168(3):101-3

“Emergency Visits for Prescription Opioid Overdose (letter to editor)," Ruan X, Bydalek K, Kaye AD, Clinical Journal of Pain, 2016, May;32(5):459. doi: 10.1097/AJP.0000000000000330

“Is Genicular Nerve Radiofrequency Ablation Safe? A Literature Review and Anatomical Study,” Kim SY, Le PU, Kosharskyy B, Kaye AD, Shaparin N, Downie SA, Pain Physician, 2016 Jul;19(5):E697-705

“Patient Satisfaction and Short-Term Outcome in Elective Cranial Neurosurgery (letter to the editor)," Ruan X, Bydalek K, Kaye AD. Neurosurgery, 2016, Jan;78(1):E162-3. doi: 10.1227/NEU.0000000000001051

“Toxicological Testing When Evaluating Fatal Cases Suspected of Acute Fentanyl Toxicity,” Ruan X, Chiravuri S, Kaye AD. Forensic Science, Medicine and Pathology, 2016 Jul 7

“Comparing fatal cases involving U-47700,” Ruan X, Chiravuri S, Kaye AD, Forensic Science, Medicine and Pathology, 2016 Jul 16

“Disclosure Without or With Reservation? Contemplating the Development of Persistent Postsurgical Pain Due to Nocebo Effect,” Ruan X, Kaye AD. American Journal of Surgery, 2016 Jun 23. pii: S0002-9610(16)30304-X. doi: 10.1016/j.amjsurg.2016.04.013

“Loeys-Dietz Syndrome: Perioperative Anesthesia Considerations,” Johnson JG, Bray JP, Risher WH, Kaye AD, MEJA, 23 (5), June 2016; 569-576

“Comparing Fatal Cases Involving U-47700,” Ruan X, Chiravuri S, Kaye AD. Forensic Science, Medicine and Pathology, 2016 Jul 16

“Determination of the Unbound Fraction of R- and S-Methadone in Human Brain,” Ruan X, Mancuso KF, Kaye AD. International Journal Legal Medicine, 2016 Jul 25

“Nalfurafine Hydrochloride, a Selective κ Opioid Receptor Agonist, Has No Reinforcing Effect on Intravenous Self-Administration in Rhesus Monkeys,” Ruan X, Hall SM, Kaye AD. Journal of Pharmacological Science, 2016 May 30. pii: S1347-8613(16)30059-7. doi: 10.1016/j.jphs.2016.05.007

“Methadone Analgesia in the Critically Il,.” Ruan X, Kaye AJ, Kaye AD, Journal of Critical Care, 2016 Jul 16. pii: S0883-9441(16)30214-3. doi: 10.1016/ j.jcrc.2016.06.036

“Increased Risk of Depression Recurrence After Initiation of Prescription Opioids in Noncancer Pain Patients,” Ruan X, Kaye AD, Chiravuri S. Pain Journal, 2016 Aug;17(8):944-5. doi: 10.1016/j.jpain.2016.05.002

“Buprenorphine Versus Methadone for Opioid Dependence in Pregnancy,” Ruan X, Bordelon GJ, Kaye AD. Annals of Pharmacotherapy, 2016 Aug 1. pii: 1060028016659889

“Intravenous Heroin Abuse and Acute Myocardial Infarction: Association or Causality,” Ruan X, Tiemann DD, Kaye AD. American Journal of Forensic Medicial Pathology, 2016 Aug 4

“Remimazolam: Pharmacologic Considerations and Clinical Role in Anesthesiology,” Wesolowski AM, Zaccagmomp MP, Malapero RJ, Kaye AD, Urman RD. Pharmacotherapy, 2016. Aug 6. Doi 10.10002/phar.1806

“Systematic Review of Cervical Medial Branch Thermal Radiofrequency Neurotomy is not Based on Peer Review Published Methodology,” Manchikanti L, Kaye AD, Hirsch JA. Pain Medicine, 2016 Aug 11. pii: pnw191

“The Patterns of Utilization of Interscalene Nerve Blocks for Total Shoulder Arthoplasty in the United States,” Gabriel R, Nagrebetsky A, Kaye AD, Dutton RP, RD Urman, Anesthesia & Analgesia, 2016 Sep;123(3):758-761

“Discordant reporting of nonmedical opioid use,” Ruan X, Chiravuri S, Kaye AD. American Journal of Drug and Alcohol Abuse, 2016 Aug 24:1-2

Response to "Off-Label Drug Use: Whose Interests Are Served?" Ruan X, Kaye AD. American Journal of Medical Quality, 2016 Aug 25. pii: 1062860616665905

“Efficacy of Percutaneous Adhesiolysis in the Treatment of Lumbar Post Surgery Syndrome,” Manchikanti L, Manchikanti KN, Gharibo CG, Kaye AD. Anesthesiology Pain Medicine, 2016 Mar 7;6(2):e26172. doi: 10.5812/aapm.26172v2. eCollection 2016